Prostate cancer is the most commonly diagnosed solid organ tumor in men in the United States, with a lifetime risk of 1 out of 6. The lifetime risk of dying from prostate cancer is 2-3%. In 2015, it is estimated that 220,000 men were diagnosed with prostate cancer, and 27,500 men died from it. Prostate cancer is the second leading cause of cancer death in men after lung cancer.
A diagnosis of prostate cancer may lead to anxiety and worsened mental health, and the treatment of prostate cancer may have quality-of-life trade-offs, such as urinary incontinence and erectile dysfunction. Therefore, a man's age, overall health, and life expectancy are critical considerations when considering whether to pursue PSA screening and biopsy for prostate cancer diagnosis and potential subsequent definitive treatment.