Older age is a risk factor for prostate cancer. Autopsy studies have shown that 30% of men in the 5th decade of life have evidence of prostate cancer versus 50% of men in the 8th decade of life. In the United States, 60% of men with prostate cancer are diagnosed after the age of 65 years.
Prostate cancer is also diagnosed more commonly in African-American men compared to white men. In addition, it is less commonly diagnosed in Asian men and Hispanic/Latin-American men compared to white men. Although reasons for this variation in prostate cancer incidence by race remain unclear, it is thought that differences in animal protein and fat intake may contribute.
Obesity is also associated with a higher incidence of prostate cancer. Family history of prostate cancer in a primary relative (biologic father and/or brother) has also been implicated in contributing to a greater risk of prostate cancer.
In the below video, Dr. Christopher Barbieri discusses how genomics & DNA repair defects play a role in an individual's risk of developing prostate cancer, and furthermore, how the indentification of specific molecular sub-types of prostate cancer can impact individual treatment paths: