Weill Cornell Medicine Urology
Weill Cornell Medicine Urology


Find a Physician


Quickly search our world-class physicians and faculty by keyword, location and insurance provider.


Dr. Poppas - Genital and Reproductive Atypical Development Program Prioritizes Multidisciplinary Care of Pediatric Patients With Disorders of Sex Development

Genital and Reproductive Atypical Development Program Prioritizes Multidisciplinary Care of Pediatric Patients With Disorders of Sex Development

The Genital and Reproductive Atypical Development (GRAD) program developed at NewYork-Presbyterian Hospital provides world-class care for patients with congenital atypical genitalia and reproductive development.

The Iris Cantor Men’s Health Center

Appointments: (646) 962-4811

The Iris Cantor Men's Health Center offers a complete and comprehensive array of healthcare services for men at a single clinical location in New York City. The objective of the Center is to provide an integrated, one-stop medical experience for men's healthcare. This center provides comprehensive care under specialties including Preventative Medicine, Internal Medicine, Endocrinology, Cardiology, Urology, Rehabilitation Medicine, Nutrition, Plastic Surgery, and Clinical Genetics.

Genitoplasty - Treatment Options

Surgical Treatment

Once a child with adrenal hyperplasia has undergone medical evaluation and begun necessary treatment, the reconstructive aspects of care can be addressed. In conjunction with surgery, children with disorders of sexual differentiation should undergo counseling to help both the parents and child cope with physical and developmental anomalies caused by the syndrome.

Genitoplasty - Symptoms & Evaluation

Medical Treatment

The major cause of morbidity and mortality in children with adrenal hyperplasia is the salt-wasting crisis. The enzyme defects most commonly associated with mortality are the salt-wasting 21-hydroxylase defect and the 3B-hydroxysteroid dehydrogenase deficiency. Fatalities were commonplace in the past because this syndrome went unrecognized. In Hendren's landmark 1969 paper, all seven patients described were salt-wasting CAH females who were inappropriately assigned as males.

Genitoplasty - Risks & Causes

Enzymatic Defects


As noted before, the most common enzymatic defect is the 21-hydroxylase enzyme. Also common are 11B hydroxylase and 3B-hydroxysteroid dehydrogenase defects. When a defect occurs in this pathway, cortisol, the end product, is deficient or completely absent. ACTH becomes elevated due to impairment of the negative feedback loop. A buildup of steroid synthesis intermediaries occurs along with excess products of alternate adrenal hormonal pathways. Subsequently the adrenal achieves a state of hyperstimulation known as hyperplasia.


CAH refers to a group of disorders that manifests with varying degrees of physical stigmata including virilization of female patients. In other words, the females born with this disease exhibit varying degrees of masculinzation of their genitalia. The degree of stigmata differs according to the underlying enzyme deficit altering cortisol formation in the adrenal gland. The most commonly encountered defect is of the 21-hydroxylase enzyme.

Brady Urologic Health Center

The Brady Urologic Health Center is located within an 8,000 square foot suite on the ninth floor of the Starr Pavilion at Weill Cornell Medicine/New York-Presbyterian Hospital and is composed of a close-knit team of physicians, working together to provide treatment for the broad spectrum of urologic conditions.

Find a Physician FIND A PHYSICIAN

© 2016 Weill Cornell Medicine All rights reserved.