The Weill Cornell Medicine (WCM) Klinefelter Syndrome Care Center offers multidisciplinary care for children and adults with Klinefelter syndrome. Co-directed by Dr. Peter Schlegel of Urology and Dr. Lilian Cohen of Medical Genetics, our program brings together a broad team of experts to offer our patients comprehensive evaluation and subspecialty care. Our goal is to provide the best care based on advances in health information and evidence-based treatment. We are part of the Association of X and Y Variations (AXYS) and the AXYS Clinic Consortium with ongoing efforts to improve clinical care, education, and research.
What is Klinefelter Syndrome?
Klinefelter syndrome is a genetic condition that occurs when a boy is born with an extra copy of the X chromosome. 47, XXY is the most common of the X and Y variants and approximately, 1 in 500 males has an extra copy of the X chromosome. We see families at all ages for genetic counseling and coordination of care. With advances in prenatal screening, families may be referred for genetic counseling and clarification about a new diagnosis. Children and adults with 47, XXY may present with subtle or varying symptoms without obvious physical differences. There may be growth or developmental concerns in early childhood for which referrals are needed in endocrinology, developmental/behavioral pediatrics, or speech/language therapy.
From adolescence to young adulthood, our endocrinologists and urologists can individualize care and treatment to meet specific needs, such as testosterone replacement and fertility management. Adults may often not be detected with 47, XXY until an infertility evaluation, while others who have known about their diagnosis for years may now need fertility-related care or genetic counseling for reproductive planning.
Peter N. Schlegel, MD
James Kashanian, MD
Dix Poppas, MD
Medical Genetics-Pediatric and Adult
Lilian L. Cohen, MD MPH
Jennifer Bassetti, MD
Katherine Bergstrom, MS, CGC
Tessa Rootenberg, MS, CGC
Zoltan Antal, MD
Oksana Lekarev, DO
Melissa Katz, MD
Vivian Rusinek Sobel, MD
Jennifer F. Cross, MD
Elizabeth Poole-Di Salvo, MD MPH
Belinda Oyinkan Marquis, MD.
Speech and Language Pathology
Yvonne Knapp, MS
Jessica S. Spat-Lemus, PhD
Would you like an appointment?
With leadership between Urology, Endocrinology, and Medical Genetics, we have a multidisciplinary team of specialists to provide care at all ages. Dr. Schlegel in Urology and Dr. Cohen in Genetics will serve as initial points of contact depending on referral concerns. After an initial evaluation, families will receive a comprehensive report with recommendations and a care plan to coordinate with their health providers. Patients and their families are also welcome to make appointments directly with providers for specific needs.
For new appointments or general inquiries, please contact Dr. Lilian Cohen at Tel: 646-962-2205
Our center sees all ages from prenatal, early childhood, adolescence to adulthood.
Address: 505 East 70th St. 3rd Floor
New York, NY 10021
For adult urology appointments, please contact Dr. Peter Schlegel at Tel: 212-746-5491 or Dr. James Kashanian at Tel 212-746-5309.
Address: 525 East 68th St. Starr 946
New York, NY 10065
For pediatric urology appointments, please contact Dr. Dix Poppas at Tel: 212-746-5337.
For pediatric endocrinology appointments, please contact Dr. Zoltan Antal or Dr. Oksana Lekarev at Tel: 646-962-3442.
For adult endocrinology, please contact Tel 646-962-8690.
Adolescent Medicine/General Pediatrics
Jane Chang, MD
Lisa Ipp, MD
Physical Medicine and Rehabilitation
Dara Jones, MD
Belinda Oyinkan Marquis, MD.
Lynda Nwabuobi, MD
Yevgeny Azrieli, MD